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Gene therapy offers a new treatment paradigm for curing human disease. Rather than altering the disease phenotype by using agents that interact with gene products, or are themselves gene products, gene therapy can theoretically modify specific genes resulting in disease cure following a single administration.
Initially gene therapy was envisioned for the treatment of genetic disorders, but is currently being studied for use with a wide range of diseases, including cancer, peripheral vascular disease, arthritis, Neurodegenerative disorders and other acquired diseases.
Certain key elements are required for a successful gene therapy strategy. The most elementary of these is that the relevant gene be identified and cloned. Upon completion of the Human Genome Project, gene availability will be unlimited. Once identified and cloned, the next consideration must be expression of the gene. Questions pertaining to the efficiency of gene transfer and gene expression remain at the forefront of gene therapy research, with current debates revolving around the transfer of desired genes to appropriate cells, and then to obtaining sufficient levels of expression for disease treatment. With luck, future research on gene transfer and tissue-specific gene expression will resolve these issues for the majority of gene therapy protocols.
Other important considerations for a gene therapy strategy include a sufficient understanding of the pathogenesis of the targeted disorder, potential side effects of the gene therapy treatment, and a more in depth understanding of the target cells which are to receive gene therapy.
Gene transfer vector is the mechanism by which the gene is transferred into a cell. Currently there are at least 150 clinical gene therapy protocols worldwide. Since the approval process for these protocols is not as public outside the U.S., it is difficult to ascertain the exact number of worldwide protocols. As of December 1995, 1024 patients had been treated with either a gene transfer or gene therapy protocol.
Much controversy exists regarding how many of these patients have benefited from their gene therapy, and no one has yet been cured.
Public controversy in the field of human gene therapy is driven by several factors. Ordinary citizens as well as scientists easily understand the enormous potential of gene therapy, but the former may not appreciate all the pitfalls and uncertainly that lie in the immediate future. The financial interests of biotechnology firms and, some have asserted the career interests of some gene therapists have encouraged extravagant, or at least verily optimistic public statements about contemporary gene therapy. In spite of the proliferation of protocols, the actual number of patients treated remains small, and only one genuinely controlled study of human gene therapy has been published as of this date.
In the passage, the author anticipates which of the following as a possible obstacle to the introduction of gene therapy to mainstream medicine?
A. The relatively small number of controlled studies of human gene therapy published as of this date.
B. Unchecked financial interests of biotechnology firms.
C. Hazards of which the general public is currently unaware.
D. The general public's difficulty in grasping gene therapy's vast potential.
E. Overly optimistic public statements given by scientists who have a vested interest
Answer: C
The best answer is E.
The passage states that both ordinary citizens and scientists understand potential of gene therapy, but the former, i.e. the general public may not appreciate all the pitfalls and uncertainty that lie in the immediate future.

Which two advanced WLAN options are required when deploying central web authentication with Cisco ISE? (Choose two.)
C. DHCP Addr. Assighment disabled.
D. Allow AAA Override enabled.
E. P2P Blocking Action set to Drop.
Answer: A,D
The WLC configuration is fairly straightforward. Atrickis used (same as on switches) in order to obtain the dynamic authentication URL from the ISE (since it uses Change of Authorization (CoA), a session must be created and the session ID is part of the URL). The SSID is configured in order to use MAC filtering. The ISE is configured in order to return an access-accept even if the MAC address is not found, so that it sends the redirection URL for all users.
In addition to this, RADIUS Network Admission Control (NAC) and Authentication, Authorization, and Accounting (AAA) Override must be enabled. The RADIUS NAC allows the ISE to send a CoA request that indicates that the user is now authenticated and is able to access the network. It is also used for posture assessment, in which case the ISE changes the user profile based on the posture result.
Ensure that the RADIUS server has RFC3576 (CoA) enabled, which is by default.
Reference: web-auth-00.html

In which of the following testing methodologies do assessors use all available documentation and work under no constraints, and attempt to circumvent the security features of an information system?
A. Full operational test
B. Paper test
C. Walk-through test
D. Penetration test
Answer: D
Explanation: A penetration testing is a method of evaluating the security of a computer system or network by simulating an attack from a malicious source. The process involves an active analysis of the system for any potential vulnerabilities that may result from poor or improper system configuration, known or unknown hardware or software flaws, or operational weaknesses in process or technical countermeasures. This analysis is carried out from the position of a potential attacker, and can involve active exploitation of security vulnerabilities. Any security issues that are found will be presented to the system owner together with an assessment of their impact and often with a proposal for mitigation or a technical solution. The intent of a penetration test is to determine feasibility of an attack and the amount of business impact of a successful exploit, if discovered. It is a component of a full security audit. Answer: C is incorrect. A paper test is the least complex test in the disaster recovery and business continuity testing approaches. In this test, the BCP/DRP plan documents are distributed to the appropriate managers and BCP/DRP team members for review, markup, and comment. This approach helps the auditor to ensure that the plan is complete and that all team members are familiar with their responsibilities within the plan. Answer: D is incorrect. A walk-through test is an extension of the paper testing in the business continuity and disaster recovery process. In this testing methodology, appropriate managers and BCP/DRP team members discuss and walk through procedures of the plan. They also discuss the training needs, and clarification of critical plan elements. Answer: A is incorrect. A full operational test includes all team members and participants in the disaster recovery and business continuity process. This full operation test involves the mobilization of personnel. It restores operations in the same manner as an outage or disaster would. The full operational test extends the preparedness test by including actual notification, mobilization of resources, processing of data, and utilization of backup media for restoration.

What should a valid iSCSI qualified name include?
A. initials of company name
B. the iSCSI string
C. date code, in yyyy-mm format
D. the WWN string
Answer: C
Reference: com.vmware.vsphere.server_configclassic.doc_40/esx_server_config/introduction_to_storage/ c_understanding_iscsi_naming_and_addressing.html